![]() While WBC and neutrophil counts were found to be higher than normal in 84 and 77 subjects, respectively, in the AA group, they were normal or lower than normal in 16 and 23 cases, respectively. WBC: White Blood Cell Count PLT: Platelet MPV: Mean Platelet Volume 13) statistical program was used for all the statistical computations. Statistical significance levels were considered as 5%. The cut-off values of parameters for discrimination of the control and patient groups were determined using the ROC analysis. The Pearson correlation analysis was carried out to examine the linear relationships among the variables. The Student t test was used to compare the means of the control and the patient groups for the studied variables. Statistical Analysis: Descriptive statistics for the studied variables (characteristics) were presented as mean, standard deviation, minimum and maximum values. ![]() The normal MPV reference value was accepted as 8.9☑.29 fL (12) 12. Normal WBC, neutrophil and platelet counts were accepted as 4–11×10 9/L, 2–8×10 9/L and 150–400×10 9/L, respectively, according to reference values of the hematology laboratory. White blood cell (WBC), neutrophil, platelet counts and MPV values of the patients were recorded. In all the cases, complete blood count was studied using horiba ABX Pentra DX 120 automatic blood count device in two hours after 4.5 ml of blood had been drawn from the antecubital vein into tubes containing 15% ethylene diamin tetra acetic acid (K3EDTA). Laboratory tests were studied in the hematology laboratory of the hospital. The healthy control group was chosen among children aged 1 to 15 years, who had been admitted to the pediatrics clinic, who did not have heart failure, peripheral vascular disease, hematologic disease, acute or chronic infections, liver disease, and who did not use anticoagulant or steroids. Patients who had been operated on with the preliminary diagnosis of AA in the light of clinical, laboratory findings and imaging methods, and in whom the definite diagnoses were confirmed with post-operative pathological examination were enrolled in the study. The study design was approved by the Ethics Committee of Yuzuncu Yil University. In this study, we aimed to investigate the diagnostic value of MPV in acute appendicitis at childhood.Ĭurrent study was carried out with 100 patients diagnosed as acute appendicitis chosen retrospectively among patients admitted to the Pediatrics and Pediatric surgery clinics of Diyarbakir Children's Hospital between 20, and 100 healthy individuals. There are available studies performed on adults available indicating that MPV values may be a valuable method in the diagnosis of acute appendicitis 11. Platelet volume is known to be a marker determined from megakaryocytes during platelet production, which is associated with platelet function and activation 6 – 10. The mean platelet volume (MPV) is a parameter detected during routine blood count and to which clinicians do not usually pay attention. However, the results of these studies have been found distinct and conflicting 3. Thus, many studies investigating the diagnostic value of laboratory inflammatory markers have been carried out in recent years. ![]() ![]() New markers are needed that would decrease the rate of negative laparatomies in cases with the prediagnosis of AA and that would not lead to a delay in the diagnosis, that would be easily applicable everywhere, be cheap, non-invasive, and that would not cause a loss in time. Thus, determining new methods to distinguish non-specific abdominal pain from AA and decreasing the rate of negative laparatomy is still required. Imaging methods such as ultrasonography and computerized tomography are promising for the early and accurate diagnosis, however, they are not sufficient 4 – 5. Unfortunately, clinical history, physical examination and routine laboratory tests do not provide sufficient data to confirm the diagnosis of AA in the early period. Furthermore, negative exploration rates still are 20–30% 1 – 3. ![]() Delay in the diagnosis of AA leads to an increase in the risk of severe and advanced complications such as perforation. The clinical diagnosis of acute appendicitis (AA) in children is still problematic. ![]()
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